Can diazepam be given intranasal?
It is substantially faster to administer diazepam intranasally to patients with status epilepticus than intravenously, leading to faster seizure termination. Intranasal diazepam appears to be a safe and effective means of terminating status epilepticus that could be employed by health care providers outside hospitals.
Is there a generic for Valtoco?
No. There is currently no therapeutically equivalent version of Valtoco available in the United States. Note: Fraudulent online pharmacies may attempt to sell an illegal generic version of Valtoco. These medications may be counterfeit and potentially unsafe.
Is Valtoco FDA approved?
VALTOCO was approved by the FDA on January 10, 2020, for the acute treatment of intermittent, stereotypic episodes of frequent seizure activity (ie, seizure clusters, acute repetitive seizures) that are distinct from a patient’s usual seizure pattern in adult and pediatric patients 6 years of age and older.
Is Valtoco a controlled substance?
VALTOCO is a prescription medicine used for the short-term treatment of seizure clusters (also known as “episodes of frequent seizure activity” or “acute repetitive seizures”) in patients 6 years of age and older. VALTOCO is a federally controlled substance (CIV) because it can be abused or lead to dependence.
How do you administer intranasal diazepam?
Hold the device with your thumb on the bottom of the plunger and your first and middle fingers on either side of the nozzle. Gently insert the tip of the nozzle into the nostril until your fingers are against the bottom of the patient’s nose. Press the bottom of the plunger firmly with your thumb to give a dose.
Is intranasal midazolam FDA approved?
The U.S. Food and Drug Administration approved the use of NAYZILAM® (midazolam) nasal spray CIV this week for use in children age 12 and over and adults with epilepsy. Nayzilam is a rescue therapy for acute (immediate, short-term) treatment of intermittent, stereotypic episodes of frequent seizure activity.
Is Valtoco new?
The U.S. Food and Drug Administration (FDA) has approved Valtoco® (diazepam nasal spray). This is a new seizure medicine designed to treat periods of frequent seizures or cluster seizures that are distinct from the person’s usual seizure pattern.
What is the brand name for diazepam?
Valium is a brand name for the drug diazepam, and Xanax is a brand name for the drug alprazolam. Both of these drugs are minor tranquilizers. They work by helping to boost the activity of gamma-aminobutyric acid (GABA).
Who manufactures Valtoco?
SAN DIEGO, CA – January 13, 2020 – Neurelis, Inc., today announced that the U.S. Food and Drug Administration (FDA) has approved VALTOCO® (diazepam nasal spray) as an acute treatment of intermittent, stereotypic episodes of frequent seizure activity (ie, seizure clusters, acute repetitive seizures) that are distinct …
Why diazepam is given slowly?
In pediatric use, in order to obtain maximal clinical effect with the minimum amount of drug and thus to reduce the risk of hazardous side effects, such as apnea or prolonged periods of somnolence, it is recommended that the drug be given slowly over a three-minute period in a dosage not to exceed 0.25 mg/kg.
How long does intranasal midazolam last?
Midazolam is well absorbed after it is given into the nose. It reaches peak amounts in the blood in about 17 minutes. The half-life in adults is between 2 to 6 hours. A half-life refers to how long it takes for the body to get rid of half of the drug.
Is Valtoco a diazepam?
Diazepam, the active ingredient in VALTOCO, has been used by doctors and nurses for more than 50 years in the treatment of epilepsy. And for more than 20 years, patients and their care partners have used diazepam as a rescue treatment for episodes of frequent seizure activity outside the medical setting.