What causes acute generalized Exanthematous Pustulosis?
In approximately 90 percent of cases, AGEP is caused by drugs, most often antibiotics (eg, aminopenicillins and macrolides), antifungals, the calcium channel blocker diltiazem, and antimalarials [3].
How do you get rid of acute generalized Exanthematous Pustulosis?
Acute generalized exanthematous pustulosis (AGEP) is most commonly caused by antibiotics (eg, aminopenicillins, macrolides, cephalosporins) followed by calcium channel blockers. The main treatment of AGEP is discontinuation of the culprit medication, which typically results in resolution within 2 weeks.
What type of adverse drug reaction is a acute generalized Exanthematous Pustulosis?
Key Messages. Acute generalised exanthematous pustulosis (AGEP) is a type IV (T-cell mediated) hypersensitivity reaction. Over 90 percent of cases of AGEP are caused by medicines, most commonly antibiotics. AGEP typically resolves spontaneously following withdrawal of the causative medicine.
Is AGEP life threatening?
Antibiotics are known to cause severe cutaneous adverse reactions, such as the rare acute generalized exanthematous pustulosis (AGEP). Unlike Stevens-Johnson syndrome or toxic epidermal necrolysis, AGEP is rarely life-threatening.
How do you treat AGEP?
New medicines should be discontinued following the onset of AGEP, particularly antibiotics. Treatment is then based around relieving symptoms with moisturisers, topical corticosteroids, oral antihistamines, and analgesics until the rash resolves. Systemic therapy is rarely indicated.
What drugs cause Exanthematous Pustulosis?
Although many causative factors leading to AGEP have been described, it is, in over 90% of cases, associated with the ingestion of drugs [5,6]. Aminopenicillins, pristinamycin, sulphonamides, quinolones, hydroxychloroquine, terbinafin and diltiazem are the most frequent causative drugs [7].
What does AGEP look like?
AGEP is characterized by sudden skin eruptions that appear on average five days after a medication is started. These eruptions are pustules, i.e. small red white or red elevations of the skin that contain cloudy or purulent material (pus).
What is pustular dermatosis?
INTRODUCTION. Subcorneal pustular dermatosis (SPD), also known as Sneddon-Wilkinson disease, is a rare neutrophilic dermatosis in which recurrent crops of sterile pustules appear in the most superficial (subcorneal) layers of the skin (picture 1A-B).
What is Exanthematous disease?
1. a skin eruption or rash. 2. a disease in which skin eruptions or rashes are a prominent manifestation. exanthem su´bitum roseola infantum.
How can you tell the difference between pustular and AGEP psoriasis?
Some criteria favor the pustular psoriasis diagnosis – history of psoriasis, prolonged fever, pustular rash of longer duration than in AGEP, absence of history of drug exposure and a differentiated histopathological picture.