What is macrocytic Normochromic anemia?
Macrocytosis is a condition in which your red blood cells are larger than they should be. While it isn’t a condition of its own, macrocytosis is a sign that you have an underlying health condition and may lead to a severe form of anemia called macrocytic normochromic anemia.
What is macrocytic anemia caused by?
Macrocytic anemia, then, is a condition in which your body has overly large red blood cells and not enough normal red blood cells. Different types of macrocytic anemia can be classified depending on what’s causing it. Most often, macrocytic anemias are caused by a lack of vitamin B-12 and folate.
How does hypothyroidism cause macrocytic anemia?
Anemia associated with hypothyroidism is usually normocytic or macrocytic. Because thyroid hormone stimulates the production of erythropoietin and affects hematopoiesis, a reduction in thyroid hormone production may cause anemia.
What lab values indicate macrocytic anemia?
Macrocytic anemia refers to macrocytosis (mean corpuscular volume (MCV) greater than 100 fL) in the setting of anemia (hemoglobin less than 12 g/dL or hematocrit (Hct) less than 36% in nonpregnant females, hemoglobin less than 11 g/dL in pregnant females, or hemoglobin less than 13 g/dL or Hct less than 41% in males).
How is macrocytic anemia treated?
Management of macrocytosis consists of finding and treating the underlying cause. In the case of vitamin B-12 or folate deficiency, treatment may include diet modification and dietary supplements or injections. If the underlying cause is resulting in severe anemia, you might need a blood transfusion.
Can hypothyroidism cause hemolytic anemia?
The shape of peripheral red cells also returned to normal after treatment. These findings suggest that the derangement of the red cell membrane lipids and plasma lipids derived from hypothyroidism can be a major cause of hemolysis in this patient.
Is anemia related to hypothyroidism?
Anemia in Hypothyroidism The low thyroid hormone levels of hypothyroidism suppress the activity of bone marrow, the tissue that makes red blood cells. That lowers the production of red blood cells and triggers anemia.