What are symptoms associated with McCune-Albright syndrome?
McCune-Albright syndrome may also affect the thyroid. The thyroid gland, located at the base of the neck, may become enlarged. About half of people with the syndrome produce excess thyroid. Symptoms include a fast heart rate, high blood pressure, weight loss, tremors and sweating.
Is McCune-Albright rare?
McCune-Albright syndrome occurs in 1 in 100,000 to 1 in 1,000,000 people worldwide.
How many people have McCune-Albright?
McCune-Albright syndrome affects males and females in equal numbers. Precocious puberty is more common in females. The disorder is estimated to affect 1 in 100,000 to 1 in 1,000,000 individuals in the general population.
Is McCune-Albright syndrome malignant?
Malignant transformation of fibrous dysplasia lesions has been reported in patients with fibrous dysplasia/McCune-Albright syndrome (FD/MAS). Recently, we have observed an increased risk for breast cancer.
Is McCune-Albright syndrome fatal?
McCune-Albright syndrome causes scars on bone tissue (fibrous dysplasia), skin pigmentation and increased function of growth-regulating glands. The condition can be fairly mild in some, and quite severe to life-threatening in others.
What causes McCune-Albright syndrome?
McCune-Albright syndrome is caused by a change in the GNAS1 gene . The change causes the GNAS1 gene to become more active than usual. The gene change is not inherited from the parents, nor is it present at the time of conception. The change actually occurs in an early cell division in the developing embryo.
Is McCune-Albright syndrome painful?
Other symptoms of McCune-Albright syndrome that affect the bones include: Asymmetrical bone growth of the face. Bone pain and discomfort. Loss of mobility.
What is Albright dystrophy?
Albright’s hereditary osteodystrophy (AHO) is a rare disorder with a wide range of signs and symptoms, including short stature , obesity, round face, subcutaneous ossifications (formation of bone under the skin), and short fingers and toes ( brachydactyly ).[1101][5576] When the disorder is inherited from the mother.
How is McCune-Albright syndrome treated?
How is McCune-Albright syndrome treated?
- Medicine to treat bone growth symptoms like bisphosphonates, which reduce the risk of bone fractures.
- Medicine to treat early puberty like aromatase inhibitors.
- Medicine to treat hyperthyroidism like antithyroids.
Why does McCune-Albright syndrome cause precocious puberty?
Precocious puberty in McCune-Albright syndrome is gonadotropin-independent. This means that it is not caused by early release of gonadotropins (luteinizing hormone and follicle-stimulating hormone), but, instead, the cause is the early secretion of high levels of sex hormones (male androgens and female estrogens).