What cancers are associated with Cowden syndrome?
CS is characterized by a high risk of both benign and cancerous tumors of the breast, thyroid, endometrium (uterus), colorectal, kidney, and skin (melanoma). Other key features of CS are skin changes, such as trichilemmomas (skin tags) and papillomatous papules, and macrocephaly, meaning larger than average head size.
What is Bannayan Riley Ruvalcaba syndrome?
Collapse Section. Bannayan-Riley-Ruvalcaba syndrome is a genetic condition characterized by a large head size (macrocephaly ), multiple noncancerous tumors and tumor-like growths called hamartomas, and dark freckles on the penis in males.
What are the symptoms of Cowden syndrome?
Cowden Syndrome Symptoms
- Macrocephaly (a larger-than-average head size)
- Trichilemmomas (benign hair follicle tumors)
- Papillomatous papules (white, raised, smooth skin bumps located in the mouth)
- Delayed development, intellectual disability, or an autism spectrum disorder diagnosis.
What is acral keratoses?
Acral keratoses are located primarily on the dorsum of the hands and feet, and are wart-like, skin colored flat-topped papules 1–4 mm in diameter (27). Palmoplantar keratoses are translucent hard papules with or without a central pit (27).
What is PTEN mutation?
Acquired (also known as somatic) PTEN genetic mutations are one of the commonly found mutations in human cancer. These mutations have been found in many different types of cancer, including prostate cancer, uterine cancer, and some types of brain tumors.
Are thyroid nodules serious?
Thyroid nodules are solid or fluid-filled lumps that form within your thyroid, a small gland located at the base of your neck, just above your breastbone. Most thyroid nodules aren’t serious and don’t cause symptoms. Only a small percentage of thyroid nodules are cancerous.