What does a positive anti-SSA Ro mean?
A positive result for SS-A/Ro antibodies is consistent with connective tissue disease, including Sjogren syndrome, lupus erythematosus (LE), or rheumatoid arthritis. A positive result for SS-A/Ro antibodies in a woman with LE prior to delivery indicates an increased risk of congenital heart block in the neonate.
What is SSA lupus?
Anti-Ro(SSA) and La(SSB) antibody determinations have become important serologic tests in the evaluation of lupus erythematosus and Sjögren’s syndrome patients. These antibodies appear to identify a group of lupus patients with prominent skin diseases.
Does a positive SSA mean you have sjogrens?
The diagnosis of Sjögren’s syndrome (SS) in these patients is necessarily supported by a positive test for anti-Ro/SSA antibodies and/or a labial salivary gland biopsy showing focal lymphocytic sialadenitis with a focus score ≥1 (ie, “positive” lip biopsy).
What is SSA in rheumatology?
Anti-SSA autoantibodies (anti–Sjögren’s-syndrome-related antigen A autoantibodies, also called anti-Ro, or similar names including anti-SSA/Ro, anti-Ro/SSA, anti–SS-A/Ro, and anti-Ro/SS-A) are a type of anti-nuclear autoantibodies that are associated with many autoimmune diseases, such as systemic lupus erythematosus ( …
What is anti-Ro SSA or antiphospholipid antibodies?
Anti-Ro/SSA antibodies are among the most frequently detected autoantibodies against extractable nuclear antigens and have been associated with systemic lupus erythematosus (SLE) and Sjögren’s syndrome (SS).
Is anti-Ro An ANA?
Anti-Ro/SSA antibodies may also be the only autoantibodies present in a subset of patients with “antinuclear antibody (ANA)-negative” SLE. The anti-Ro/SSA and anti-La/SSB antibody systems and the clinical significance of these antibodies are reviewed here.
What antibodies are high in Sjogren’s?
The antibodies associated with Sjogren’s include anti-Ro (SS-A) and anti-La (SS-B) antibodies, rheumatoid factor, and antinuclear antibodies.
Does lupus have a positive rheumatoid factor?
Rheumatoid factor (RF) is found commonly in patients with systemic lupus erythematosus (SLE), and has been associated with a more benign disease course.