What are the pathogenesis of tuberculosis?
Infection occurs when a person inhales droplet nuclei containing tubercle bacilli that reach the alveoli of the lungs. These tubercle bacilli are ingested by alveolar macrophages; the majority of these bacilli are destroyed or inhibited.
Can you get TB from genetics?
Conclusions: Based on different research works across the world, there is sufficient evidence to prove that TB is a genetically primed and determined infectious disease caused by M. tuberculosis and the genetic polymorphism is the mechanism that leads to progression from infection to TB disease.
What are the pathological changes in tuberculosis?
Arthur Dannenberg described the pathology of tuberculosis in detail [2, 3]. There are five stages: onset, symbiosis, early stages of caseous necrosis, interplay of cell-mediated immunity and tissue damaging delayed-type hypersensitivity, and liquefaction and cavity formation.
What is the mechanism of pathogenesis?
Pathogenesis is the process by which an infection leads to disease. Pathogenic mechanisms of viral disease include (1) implantation of virus at the portal of entry, (2) local replication, (3) spread to target organs (disease sites), and (4) spread to sites of shedding of virus into the environment.
Does TB run in families?
While it is possible to catch TB from a family member, you should be aware that: only TB of the lungs or throat is infectious, so if someone has another type of TB you cannot catch it from them. TB is a bacterium, so it is not spread in the same way as a cold virus.
Can TB be passed from father to child?
A child usually does not become infected unless they have repeated contact with the bacteria. TB is not spread through personal items, such as clothing, bedding, cups, eating utensils, a toilet, or other items that a person with TB has touched.
How many genes does tuberculosis have?
4,000 genes
tuberculosis genome is 4.4 million base pairs long and encodes for approximately 4,000 genes (Cole et al., 1998).